Soft Elastic Gelatin Capsules
Product Description
Softgels as they are commonly known today utilize a gelatin solution that is plasticized with propylene glycol sorbitol glycerin or various approved mixtures. Soft gelatin capsules are one-piece and hermetically sealed to enclose a liquid or semi-liquid fill. Soft gelatin capsules are manufacture-formed filled and sealed in one continuous operation.
The soft gelatin encapsulation process begins with the formation of two sheets called ribbons from a molten gelatin mass each of which is passed over a die of the desired capsule size and shape. At the point where the two rotating dies meet the capsule is formed and filled with a liquid that contains the active ingredient in a vehicle. The capsule is then washed to remove the lubricants and dried.
In 1932 R. P. Scherer developed the first rotary die encapsulation system: since that time the technology has been refined into a completely automatic process. The rotary die method has the advantage of producing a capsule with highly accurate dosage levels can prevent photochemical deterioration of the active ingredient and masks unpleasant tastes.
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