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PEG-G-CSF(Pegfilgrastim) is a covalent conjugate of recombinant methionyl human G-CSF and monomethoxypolyethylene glycol. G-CSF is a water-soluble 175 amino acid protein with a molecular weight of approximately 19 kilodaltons (kD).  G-CSF is obtained from the bacterial fermentation of a strain of Escherichia coli transformed with a genetically engineered plasmid containing the human G-CSF gene.  To produce pegfilgrastim, a 20 kD monomethoxypolyethylene glycol molecule is covalently bound to the N-terminal methionyl residue of G-CSF.  The average molecular weight of pegfilgrastim is approximately 39 kD.