| Model: | - |
|---|---|
| Brand: | Sinoway |
| Origin: | Made In China |
| Category: | Chemicals / Agrochemicals / Veterinary Medicine |
| Label: | ATRACURIUM |
| Price: |
¥1000
/ pc
|
| Min. Order: | 1 pc |
| Live Chat: | Last Online:09 Mar, 2018 |
Basic information of Atracurium besylate
|
Name |
Atracurium besylate |
|
Alias |
|
|
CAS NO. |
64228-81-5 |
|
Molecular Formula |
C65H82N2O18S2 |
|
Molecular Weight |
1243.48 |
|
Quality Standard |
Current USP |
|
Package Size |
2kg or 3kg/tin/carton |
|
Storage condition |
Preserve in tight,light-resistant containers and store at 2-8℃ |
Use of Atracurium besylate
COA of Atracurium Besylate
|
TEST |
STANDARD |
RESULT |
|
Description |
whiteto off-white powder, |
White powder |
|
Solubility |
Very soluble in acetonitrile, in alcohol, and in methylene chloride; soluble in water |
Conforms |
|
Identification |
A.IR spectrum of the sample should correspond to that of the Reference Standard |
Conforms |
|
B.The retention times of the three main isomeric peaks of the sample solution correspond to those of the standard solution, as obtained in the assay |
Conforms |
|
|
Water |
NMT 5.0% |
1.4% |
|
Clarity and Color of Solution |
The solution is clear and not more intensely colored than standard solution |
Conforms |
|
Residue on ignition |
NMT 0.1% |
0.06% |
|
Heavy Metals |
NMT 20ppm |
＜20ppm |
|
Impurity J |
NMT 0.001% |
＜0.001% |
|
Related Substances |
Impurity A(containing A1 and A2): Not more than 1.5% |
0.48% |
|
Impurity B: Not more than 0.1% |
＜0.006% |
|
|
Impurity C(containing C1 and C2): Not more than 1.0% |
0.25% |
|
|
Impurity D(containing D1 and D2): Not more than 1.5% |
0.25% |
|
|
Impurity E: Not more than 1.5% |
＜0.05% |
|
|
Impurity F: Not more than 1.0% |
＜0.05% |
|
|
Impurity G: Not more than 1.0% |
0.09% |
|
|
Total of Impurity H,I and K:Not more than 1.0%: |
0.10% |
|
|
Tetrahydropapaverine: Not more than 0.10% |
＜0.05% |
|
|
Any other individual impurity: Not more than 0.1% |
＜0.05% |
|
|
Total impurities: Not more than 3.5% (Disregard any impurity less than 0.05%) |
1.2% |
|
|
Microbial Limit |
Total aerobic bacteria: Not more than 100CFU/g |
＜1cfu/g |
|
Mold and yeast: Not more than 10CFU/g |
＜1cfu/g |
|
|
E. coli. :should be absent in each 1g |
Non-detected |
|
|
Bacterial Endotoxin |
Not more than 2.0EU/mg |
＜2.0EU/mg |
|
Residue Solvents |
Ether: Not more than 5000ppm |
＜3ppm |
|
Acetone: Not more than 5000ppm |
＜8ppm |
|
|
Ethylacetate:Not more than 5000ppm |
＜16ppm |
|
|
Dichloromethane: Not more than 600ppm |
66ppm |
|
|
Ethanol: Not more than 5000ppm |
＜18ppm |
|
|
Acetonitrile: Not more than 410ppm |
10ppm |
|
|
Toluene: Not more than 890ppm |
73ppm |
|
|
Assay |
Contain 97.0% to 102.0% of C65H82N2O18S2on the anhydrous basis |
98.3% |
|
Trans-trans isomer:5.0%-6.5% |
5.5% |
|
|
Cis-trans isomer: 34.5%-38.5% |
35.9% |
|
|
Cis-cis isomer:55.0%-60.0% |
58.6% |
|
|
Conclusion |
Confirms tocurrent USP standard. |
|
