Product Description
Rutinraw
English
name: Flos sophorae immaturus, Japanese pagodatree flower-bud Synonym:
Meletin, sophoretin Origin: The flower bud of sophora japonica L Plant
morphology: Deciduous tree with height of about 15-25meters Collecting
and processing: Collect the flower bud in summer, drying timely,
removing the branches, stems and impurities Appearance: The shape of
flower bud is oval, with length of 2-6mm, diameter of about 2mm
Odorless, slightly bitter taste Chemical composition: Contains rutin,
saponin and sterol Property and Flavor: Slightly cold in nature, bitter
taste Indications: Cooling blood and hemostasis, purging liver fire, for
the treatment of hemafecia, hemorrhoidal bleeding, blood dysentery,
uterine bleeding, hematemesis, epistaxis, conjunctival hyperemia caused
by hepatopyretic disease, headache and dizziness Dosage: 4 5-9g
Rutin Products
Product name: Rutin
Synonym: Rutoside, Vitamin P, Violaquereitrin
Chemical Name:
3-{[6-0-(6-deoxy--L-mannopyranosyl)--D-glucopyranosyl]oxy}-2-(3, 4-dihyroxyphenyl)-5, 7-dihydroxy-4H-1-benzopyran-4-one.
Molecular Structure:
M. F. & M. W.: C27H30O16; 610.51
Physical
Property: Yellowish- needle - crystal (in water); M. P.: 176-8C, 23D:
+13.82C (ethanol), 20D-39.43 C (pyridine); Solubility: 1g in 7ml of
methanol, 8000ml of water, 200ml of boiling water; UV CH3OHmax nm:
258.361; IRKBr max cm-1: 3400(OH), 1670(C=O), 1620, 1520, 1470(C6H5-).
Plant
source: Ruta graveolens L., plant essential oil [2]; Sophora japonica
L., main part of fruit [3, 4]; Hypericum aseyron L., full plant;
Berchemia polyphylla Wall, var leioclada Hand. -Mazz. [5]; Mallotus
japonicus Muell. -Arg, leafs [6]; Fagopyrum esculentum Moench seedling.
Indications:
1.
Anti-inflammatory action: Apparent suppression of inflammation due to
planted wool when the product is injected into abdominal cavity of rat
[8]. Sodium rutin sulfate has very strong anti-inflammatory action to
edema of rat [9].
2. Actions like Vitamin P: Maintain the strength
of blood vessel, reduce its permeability and brittleness; Degreasing
action to liver fatty infiltration, especially together with
glutathione.
3. Antiviral action: Best suppression to phlyctenular stomatitis virus at product concentration of 200g/ml [10, 11].
4.
Inhibition of aldehyde reductase: 95% inhibition at a concentration of
10-5M [12], which facilitates the treatment of diabetic cataract.
5. Toxicity: Mice, intravenous injection, LD50 at 950mg/kg.
6.
Clinical use: For the prevention of intracerebral hemorrhage,
hypertension, retinal hemorrhage, purpura and acute hemorrhagic
nephrosonephritis; For treatment of chronic tracheitis with effective
rate at 84.8% and 98%. Its derivative, troxerutin, or Venoruton, is
applied clinically for burn, arthritis, and all kinds of blood vessel
diseases. Commodity drug is available in abroad [14], while the drug has
been successfully developed in domestic. With Effective rate for the
treatment of cerebrovascular diseases is 87.8%; 88% for retinal edema
and hemorrhage
Specification of Rutin (NF11)
Product Name: Rutin
Botanical source: Sophorae Japonica
Part of plant used: Flower
CAS #: 153-18-4
TEST
NF11
TEST METHOD
Appearance
Identification
pH
Particle size
Chlorophyll
Red-pigments
Quercetin
Bluk Density
Tapped Density
Heavy metals
-Arsenic
-Mercury
-Cadmium
-Lead
Ash
Loss on drying
Assay(on dry basis)
Yellow to greenish-yellow powder
Must positive
6.0-7.0
95% pass through 60 mesh
0.004%
0.004%
5.0%
0.40GM/cc
0.60GM/cc
10ppm
1ppm
0.1ppm
1ppm
3ppm
0.5%
5.5%-9.0%
95.0%-102.0%
Visual
Infrared Absorption
pH Meter
US Screen
UV
UV
HPLC
CP2010
CP2010
Visual Colorimetry
AAS
AAS
AAS
AAS
CP2010
120C
UV
Specification of Rutin (EP8.0)
Product Name: Rutin
Botanical source: Sophorae Japonica
Part of plant used: Flower
CAS #: 153-18-4
TEST
EP8.0
TEST METHOD
Appearance
Solubility
Identification
Particle size
Residual Solvents
Light absorbing impurities
Substance Insoluble in methanol
Related Substances
A: Isoquercetin
B. Kaempferol 3-Rutinoside
C. Quercetin
Other impurity
Total impurity
Sulphated Ash
Water
Assay(On dry basis)
Heavy metals
-Arsenic
-Mercury
-Cadmium
-Lead
Bulk Density
Tapped Density
Yellow to greenish-yellow, crystalling powder
Practically
insoluble in water, soluble in methanol, sparingly soluble in ethanol,
practically insoluble in methylene chloride, it dissolves in soluble of
alkali hydroxides
B. CRS absorbance
A. UV absorbance
C. TLC Examination
D. Color reaction with Zn
95% pass through 80 mesh
0.2%
0.10 between 450 and 800nm
3.0%
2.0%
2.0%
2.0%
0.1%
4.0%
0.10%
7.5%-9.5%
95.0%-101.0%
10ppm
1ppm
0.1ppm
1ppm
3ppm
0.30GM/cc
0.50GM/cc
Visual
Visual
CRS
TLC
UV
Visual
CP2010
HPGC
UV
CP2010
HPLC
HPLC
HPLC
HPLC
HPLC
CP2010
-Karl Fischer
Titration
Visual Colorimetry
AAS
AAS
AAS
AAS
CP2010
CP2010
Specification of Rutin (DAB10)
Product Name: Rutin
Botanical source: Sophorae Japonica
Part of plant used: Flower
CAS #: 153-18-4
TEST
DAB10
TEST METHOD
Appearance
Melting point
Identification(A/B/C)
Purity
Insoluble Matter
-Solution(a)
-Solution(b)
Particle size
Related Substances
Isoquercetin
Quercetin
Kaempferol 3-Rutinoside
Bluk Density
Tapped Density
Heavy metals
-Arsenic
-Mercury
-Cadmium
-Lead
Ash
Loss on drying
Assay(on dry basis)
Light greenish yellow powder
210C melting and decompositon
Must positive
Must Conforms
Should be clarified
Should be clarified
95% pass through 80 mesh
Must Conforms
2.0%
2.0%
2.0%
0.30GM/cc
0.50GM/cc
10ppm
1ppm
0.1ppm
1ppm
3ppm
0.10%
5.5%-8.5%
98.0%-102.0%
Visual
Infrared Absorption
pH Meter
US Screen
UV
UV
HPLC
CP2010
CP2010
Visual Colorimetry
AAS
AAS
AAS
AAS
CP2010
120C
UV
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