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Brain anti-aging nutrition
Brain health food

Choline Alfoscerate powder

Formula: C8H20NO6P MW: 257
Appearance: White to light yellow fine powder
Purity: 99% min
Packing: 5kg/foil bag; 25kg/drum
Store: Keep away from fire and heat source; hermetically deposit; keep in shady, cool and dry condition; protect against the tide.

Choline Alfoscerate Liquid

Properties: colorless transparent liquid. Soluble in water and organic solvents.
Molecular formula: C8H20NO6P
Choline Alfoscerate (GPC) L-alfa-glycerylphosphorylcholine
L-alfa-GPC

CAS No. :28319-77-9

Choline alfoscerate (also known as Alpha-GPC) is L-a-glyceryl phosphorylcholine (GPC),a key brain cell membrane phospholipid and cholinergic precursor. It is a source of choline for the synthesis of the neurotransmitter acetylcholine, with a greater ability to penetrate the blood-brain barrier than conventional choline sources.

More importantly, Choline alfoscerate has been experimentally demonstrated to reduce or reverse agerelated structural changes in the frontal cortex and hippocampus and induced functional deficiencies of the cholinergic system. Research supports choline alfoscerate's ability to support healthy brain function and the release of somatotrophin (hGH).

Main Applications of Choline alfoscerate :
As reported by literature:
•Support in Alzheimer’s disease.
•Cognitive support.
•Infant brain development.

Choline alfoscerate (al-FOSS-er-ate), or alpha-glycerylphosphorylcholine (GPC), is a phospholipid - a complex fatty substance containing phosphorus, like phosphatidylserine and phosphatidylcholine - and is an important building block in the construction of nerve cell membranes. After completing an analysis of thirteen published clinical trials, involving over 4000 patients, a group of Italian scientists concluded that "The stated therapeutic usefulness of Choline Alfoscerate in the relief of cognitive symptoms, such as memory and attention impairment, differentiates [it] from cholinergic precursors used in former clinical trials", such as choline, lecithin, or phosphatidylcholine. The reason, as evidence now s ests, is that the effects of this versatile nutrient extend well beyond its role as a mere choline source: choline alfoscerate supports the restoration of a whole spectrum of youthful cholinergic functions.

Weak Link 1: Decreased Choline Uptake
Choline alfoscerate is a rapidly absorbed source of choline, which easily enters the brain. GPC raises free plasma choline more rapidly than other uncharged choline precursors. Because it is a phospholipid - the same sort of material of which the brain and Blood-Brain Barrier (BBB) are made -Choline Alfoscerate does not carry the electrical charge of regular choline, and so freely crosses the blood-brain barrier. The choline from Choline Alfoscerate is

incorporated into brain phospholipids within 24 hours of absorption.

Weak Link 2: Enzyme Imbalances
The brain makes acetylcholine using an enzyme known as choline acetyltransferase. As we get older, ChAT activity goes down, while the activity of enzymes that break down chat goes up. As a result, aging brains make less acetylcholine from the choline available to them, while they tear acetylcholine down more quickly. Animal studies s est that Choline Alfoscerate may also improve the levels of ChAT.

Weak Link 3: Brain Drain
This is perhaps the most serious issue facing the aging brain: the cholinergic neurons of the brain simply wither away with age. The number of neurons declines, and those neurons that remain literally shrink, becoming less well-connected to the rest of the brain. This decay is made all the worse by the fact that the ability of the surviving cholinergic neurons to release and respond to ACh is also impaired with age!

Even more incredibly, animal studies show that Choline Alfoscerate actually increases the number of cholinergic neurons as well. In addition, Choline Alfoscerate may reverse the atrophy of existing cholinergic neurons, since studies show that Choline Alfoscerate increases the number of receptors for nerve growth factor (NGF). Supplying NGF to old monkeys clearly reverses cholinergic neuron atrophy, restoring the number and size of these neurons to more youthful levels.

Controlled Trials: It Works
In one controlled trial in victims of vascular dementia, greater improvements on several measures of cognitive function were seen amongst those patients treated with Choline Alfoscerate than in those given another choline precursor. The differences were statistically significant, and both patients and physicians rated the results with GPC more satisfactory.

Another controlled trial in Alzheimer's disease compared Choline Alfoscerate to acetyl-L-carnitine (ALCAR), a nutrient already proven to slow the progression of AD in younger patients. Most behavioral and mental function test results showed improvement in the Choline Alfoscerate group - and the improvements were greater than those seen in the ALCAR group.

There is also a hint that Choline Alfoscerate may prove of use in Parkinson's disease (PD). PD is characterized by reductions in the production of the neurotransmitter dopamine in an area of the brain called the substantia nigra. This leads to a loss of motor control, typically manifesting in facial ticks or tremors, dry mouth, and a "masklike" facial expression. In laboratory animals, measures of dopaminergic activity were enhanced by GPC treatment.

Choline alfoscerate, or L-Alpha Glycerylphosphorylcholine (Alpha GPC), occurs naturally in the fatty acids of soy plants. It is considered important to the synthesis of acetylcholine, a neurotransmitter that supports brain health and the production of human growth hormone(HGH). As the brain ages, acetylcholine levels typically decrease, which can lead to cognitive disorders such as dementia and Alzheimer's. Studies s est that choline alfoscerate can treat Alzheimer's and other forms of age-related cognitive decline. Evidence also s ests that this type of choline may be able to stimulate increased blood levels of human growth hormone in the elderly, for a healthier, more youthful body.

Alpha-GPC is marketed in the United States as a dietary supplement. Prescription forms ofcholine alfoscerate are administered in Europe to treat Alzheimer's disease. Dementia, stroke, and transient ischemic attack (TIA) patients may also benefit from alpha GPC use. Alpha-GPC is marketed as a dietary supplement that can enhance memory, cognitive ability and learning ability.

Unlike some other forms of choline, choline alfoscerate normally penetrates the blood-brain barrier easily. Once it has crossed the blood-brain barrier, the brain makes acetylcholine from alpha-GPC. Acetylcholine is an important neurotransmitter that is believed responsible for memory, learning, normal cognitive function and human growth hormone production.

As the brain ages, its neurons and neural receptors can atrophy, ceasing to function. Aging brains often experience significant declines in the function of memory-specific neural receptors. Choline alfoscerate may help to stimulate the growth of new neurons and neural receptors, and may help reverse the neural atrophy that can cause loss of cognitive function. As a result, alpha-GPC may be able to slow, stop, or reverse cognitive decline in those already suffering from Alzheimer's, dementia or other forms of age-related cognitive decline. It is hoped that choline alfoscerate may prove invaluable to the treatment of Alzheimer's, dementia and other age-related cognitive disorders.

Choline alfoscerate may also help boost production of human growth hormone in the elderly. While the production of human growth hormone in the brain doesn't typically decline with age, its release into the body can decline significantly. Choline alfoscerate can help stimulate the release of human growth hormone in the brains of older patients. Higher levels of HGH release can help keep elderly patients physically strong and healthy.