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Citicoline (CDP-Choline)

Chemical name: cytidine 5'-diphosphocholine

CAS No.: 987-78-0

EINECS No.: 213-580-7

Molecular Formula: C14H25N4O11P2

Formula Weight: 488.33

Citicoline (CDP-Choline) :

Citicoline is the active principle of the citicoline sodium which indications are acute

traumatic brain injury and brain consciousness after the operation, treat central nervous

system dysfunction and unconsciousness caused by acute injury, paralysis agitans, tinnitus

and nerve deafness, and poisoning caused by sleeping pills.

In recent years, Citicoline (CDP-Choline) is widely used in replenishesing brain's energy, clinical for treatment of ischemic stroke, cerebral arteriosclerosis, multi-infarct dementia, and Alzheimer’s disease, and children viral encephalitis, glaucoma.

In the USA market, Citicoline is widely used in energy shot, health food, brain nutritional supplements ect.

In Europe and Asia market, the citicoline sodium (active principle is citicoline) is injection or oral grade medicine.

Function Claims

² Citicoline (CDP-Choline)can Improve brain cell membrane structure of phospholipid synthesis ------ Enhanced intelligence

² Citicoline (CDP-Choline)Restore electrolyte balance, and promote the absorption of brain edema ------- repair brain damage

² Citicoline (CDP-Choline)Regulate neurotransmitter synthesis and release, to keep it in a suitable concentration, stability, neurons in the middle of the transmission ------anti-amnesic, anti-hypoxia

² Bioavailability:

² Safe ------ adverse reactions, no obvious side effects, safety, good.

3. Physiological Function

Citicoline is a nucleic acid that is also known as CDP-choline. It is a form of choline that serves as the raw material for the production of phospholipids in the brain. Brain cells have the ability to convert citicoline into phosphatidyl choline, the primary phospholipids component found in cell membranes.

Citicoline is believed to stabilize the membranes and, when absorbed by the body, breaks down into cytidine and choline. However, once citicoline reforms in the body, it is converted to acetylcholine, a neurotransmitter, which is involved in memory, thought, sexual function and other vital functions. Numerous studies have indicated that when taken as a supplement, citicoline can lessen the symptoms of Alzheimer’s and

Parkinson’s disease, as well as alleviate mild cognitive impairment associated with ageing and strokes.

citicoline can helps supply the nutrients which the human brain needs to stay alert and focused

The citicoline can effectively reduce damage to cell membranes