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First SignTM Drug of Abuse Test is an easy to use one-step immunoassay intended for use in the qualitative analysis for multiple drugs of abuse and its metabolites in human urine. It should not be used without proper supervision and is not intended for sale to the general public. The test provides only preliminary screening test results; a more specific alternate chemical method must be used in order to confirm the analytical result. Gas chromatography / Mass spectrometry (GC/MS) is the preferred confirmatory method (1). Clinical considerations and professional judgment should be applied to any drug of abuse analysis, particularly when positive results are indicated (2,3).