| Model: | 62-44-2 |
|---|---|
| Brand: | MF |
| Origin: | Made In China |
| Category: | Chemicals / Pharmaceutical Chemicals |
| Label: | - |
| Price: |
US $10
/ gram
|
| Min. Order: | 5 gram |
| Live Chat: | Last Online:17 Aug, 2022 |
Description
Phenacetin
Phenacetin structure
|
Common Name | Phenacetin | ||
|---|---|---|---|---|
| CAS Number | 62-44-2 | Molecular Weight | 179.216 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 323.6±44.0 °C at 760 mmHg | |
| Molecular Formula | C10H13NO2 | Melting Point | 133-136 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 149.5±28.4 °C | |
| Symbol |  
GHS07, GHS08 |
Signal Word | Danger | |
Use of Phenacetin
Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3].
Phenacetin Biological Activity
| Description | Phenacetin is a non-opioid analgesic without anti-inflammatory properties, inhibits COX-3 activity.Target: COXPhenacetin is a pain-relieving and fever-reducing drug, Phenacetin was withdrawn from the Canadian market in June 1973 due to concerns regarding nephropathy. the clinical and laboratory data were compatible with "phenacetin nephritis" as described in Europe and Australia and recently in the United States and Canada. This report evaluates the findings in the 23 cases and cautions against the use of phenacetin, particularly in patients with impaired renal function [1]. Phenacetin has been linked to renal papillary necrosis in human beings [2, 3]. | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Related Catalog |
Research Areas >> Inflammation/Immunology |
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| Target |
COX-3:102 μM (IC50) |
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| Solvent |
In Vitro: 10 mM in DMSO |
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| Solubility |
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| Storage |
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| Shipping | Room temperature in continental US; may vary elsewhere | ||||||||||||
| SMILES | CC(NC1=CC=C(OCC)C=C1)=O | ||||||||||||
| References |
[1]. Chandrasekharan NV, et al. COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13926-31. [2]. Brix, A.E., Renal papillary necrosis. Toxicol Pathol, 2002. 30(6): p. 672-4. [3]. Dubach, U.C., B. Rosner, and T. Sturmer, An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987). N Engl J Med, 1991. 324(3): p. 155-60. |
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| Related Molecules | 4-Acetamidophenol | Aspirin | Paradol | Ginsenoside Rg3 | Ginsenoside C-K | Xanthohumol | Ibuprofen | Diclofenac | NS-398 | Meloxicam | Flufenamic Acid | (-)-Epicatechin | Salicylic acid | ketoprofen | Naproxen |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 323.6±44.0 °C at 760 mmHg |
| Melting Point | 133-136 °C(lit.) |
| Molecular Formula | C10H13NO2 |
| Molecular Weight | 179.216 |
| Flash Point | 149.5±28.4 °C |
| Exact Mass | 179.094635 |
| PSA | 38.33000 |
| LogP | 2.01 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.506 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong acids. |
| Water Solubility | 0.076 g/100 mL |
Handling and Storage
Precautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
| Payment Terms: | TT |
|---|---|
