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BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.
Properties
Density: 1.237g/cm3
Boiling Point: 397.6ºC at 760 mmHg
Flash Point: 194.3ºC
Refractive Index: 1.557
Vapor Pressure: 1.57E-06mmHg at 25°C                                                                                                                                      Molecular Weight 207.3 g/mol
Molecular Formula C10H9NO2S                                                                                                                                                  Appearance:White powder                                                                                                                                                          Purity >98%
CAS 19542-67-7
Solubility Soluble in DMSO at 25 mg/ml or ethanol at 15 mg/ml.