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Description: Yohimbine HCL
Chemical Formula: C21H26N2O3.HCl
Molecular Weight: M.W. 390.9
Solubility: Soluble in Water (10 mg/ml).
CAS Number: CAS [65-19-0]
Appearance: White to Off-White Powder

Purity: >98%

1. What is yohimbine?

Yohimbine is an alkaloid found in the inner bark of a tree that grows in southern Africa, Corynanthe yohimbe. Yohimbe has been used for centuries as an aphrodisiac, and alkaloids derived from this tree have been studied in depth. Yohimbine is now used primarily in veterinary medicine and in the treatment of erectile dysfunction, and it may also be useful in the treatment of obesity.

2. What application does yohimbine have?

Yohimbine has not been researched as thoroughly in the area of fat loss as many other weight loss aids, especially where clinical trials are concerned, but the existing data is promising. A 3-week study in 1991 on 20 obese females on 1000 calorie diets found that 20 mg of yohimbine daily increased weight loss 3 lbs. over placebo. Multiple studies have found that yohimbine increases the amount of non-esterfied fatty acids (NEFAs), a product of lipolysis (the breaking down of fat), in the bloodstream in both lean and obese individuals , and that this effect persists for at least 14 days, indicating that rapid tolerance does not develop . Yohimbine is also an appetite suppressant, and decreases energy intake in both lean and obese mice.

3. What other benefits does yohimbine have?

Aside from being a fat loss agent, yohimbine is well known as a sexual stimulant. Studies indicate that it increases copulatory behavior and reduces sexual exhaustion in male rats. A recent review of the literature found that yohimbine, especially in combination with drugs that facilitate the action of nitric oxide, is effective in the treatment of male erectile dysfunction , and a study in women found yohimbine combined with L-arginine glutamate to increase sexual arousal in women with sexual arousal disorder . Yohimbine also slightly raises serum levels in men .

4. What are the side effects of yohimbine?

Anxiety is the most common side effect seen with yohimbine, especially higher doses, and for this reason it should not be used by individuals prone to panic attacks or with stress-related disorders . Other common side effects are increased heart rate and blood pressure, although these do not appear to be a problem at the doses used for weight loss . Other side effects associated with elevated levels of NE, such as insomnia, can also be expected. All of these side effects disappear after termination of use .